Immunotheraphy : Looks to be promising as a Cancer treatment

Many of us are afraid of Cancer, especially if somebody in the family have one of it. And we know that cancers have many types, almost all organs in the body have cancer type. It is very terrifying, when a doctor diagnose that you have a cancer. It feels like that this is your end. Treatments on cancer had become more advance but theirs not yet those 100% cure.

But don’t lose hope, lately a new type treatment had been discovered for cancer, however this is not new, it may be around for many years. Only this time, it had more promising result than those previous years. And only this time, many scientist focuses this type of treatment.

Chemotherapy is one of the common treatment for cancer, especially if the cancer is in the early stage of it. Chemotherapy directly attacks those cells both normal and cancerous, which means that it have many direct effects in our body. Another one treatment is operation of a certain part, this is done also in early stage if the cancer is in the breast, liver, etc. This two are best option for treating the cancer in the past few years.

Lately, a treatment called “Immunotheraphy” is currently been on studies and undergo many clinical trials. Immunotherapy is a type of treatment that uses the body’s immune system to help fight disease, especially cancer.

Types of Immunotheraphy

Drugs (Checkpoint Inhibitors), this is most common drugs being used as immunotherapy for cancer. This drug block the mechanism by cancer cells use to shut down the immune system. This will free the killer T-cells (critically important part of the immune system) to attack any tumors in the body. This drug had been approved by Food and Drug Administration. It will be given via intravenous.

Cell Theraphy, this type of immunotherapy involves in removing a cell in immune system of the patients, alters it genetically to fight cancer cells, then multiply them in the laboratory and put back to the patient via transfusion. This new type is being individually for every patient and still on the experimental stage.

Bispecific antibodies, this an alternative to cell therapy, which does not require individualizing treatment for each patient. These antibodies are proteins that can be attach both on cancer cells and T-cells, bringing them together so that T-cells can attack the cancer cells. The example drug of this, “Blincyto” which has been approved to treat the rare type of Leukemia.

Vaccines, another form of immunotherapy but it is less successful than others. Cancer vaccines are aimed to treat person that has cancer already on it. This idea is to prompt that immune system attack cancer cells when presented by some piece of cancer cells. Provenge, for prostate cancer is the only approved vaccines approved in the U.S. And another is BCG, which prevent Tuberculosis, also use to treat bladder cancer.

Types of Cancer being treated with Immunotherapy

For checkpoint Inhibitors had been approve to treat advance “melanoma”, Hodgkin’s Lymphoma, and cancers of the lungs, kidneys and bladder. But this drugs also is being tested for other cancer type.

The cell therapy is mostly used for blood cancers, such leukemia and lymphoma.

Example of Checkpoint Inhibitors

Only four are now in the market:

1.       Yervoy (ipilimumab) and Opdivo (nivulomab) by Bristol-Myers Squibb

2.       Keytruba (pembrolizumab) by Merck

3.       Tecentriq (atezolizumab) by Genentech

The effectiveness of the Immunotherapy

Most of the cases, immonutherapy have been successful but only works on the minority of the patients. About 20%-40% of the patients had been helped by Checkpoint Inhibitors, this can be higher among those patients with melanoma. Combining two Checkpoint Inhibitors increases the effectiveness. Some patients with advanced disease have a remission that lasted for years. Some patients the drug don’t work at all or being helped temporarily.

For the cell therapy, it can produce complete remissions in 25% - 90% in patients with lymphoma and leukemia, depending the type of cancer. Some cases the remission lasted for years while others have relapse for a year.

Side Effects of Immunotheraphy

Checkpoint Inhibitor drugs can cause severe problems, including autoimmune illnesses, which the immune system attacks the healthy cells as well as the cancer cells. May result on inflammation. For the lungs may cause some breathing problems, diarrhea for intestines. Joint and muscle pain, and rheumatoid arthritis can also occur. The immune system can attack also vital glands like thyroid and pituitary. This following side effects are dangerous but can be controlled by the use of “steroids medicines” such prednisone.

Also Cell Therapy, can lead to severe and potentially fatal reactions resulting the overstimulation of the immune system. This reactions though can be controlled, but many patients may need to be treated at intensive care unit.

The Cost of Immunotherapy

Checkpoint Inhibitors can cost around $150,000 per year (for U.S.). Many insurer will pay if it is being approved for the type of cancer the patients has. But this drugs can be free if the patients participate in clinical trials.

Many manufacturers don’t have any comment about the price for the cell therapy, assuming that they will the approval and reach the market. But many experts believes that it will around hundreds of thousands of dollars.

Availability of Immunotherapy

Any oncologist you have can prescribe the Checkpoint Inhibitors that are available in the market. Through volunteering for clinical trials those drug that are not been approved for certain cancer type, you may get it for free.

Cell therapies are only available through clinical trials now. Most of the major study sites are on major medical centers (U.S).

Information about clinical trials of Immunotherapy

Cancer Research Institute website

Calling this number 1-855-216-0127 (Monday through Friday, 8:30 a.m. to 6 p.m. E.T.).

ClinicalTrials.gov – another source. 

World News: Vaccine For Diabetes Recently Revealed

Did you know diabetes falls on the top five disease in the word?

Yes, it is on the top five diseased on the world right now, because millions of people suffers on it. Also, one of the leading cause of deaths because of it complications. Either endocrinological or metabolic type, this disease really affects many people around the world.

Diabetes have two types, diabetes type 1, this type is common among the children and consider to be auto-immune, while the second type, diabetes type 2 which occurs on later years which could relate on the diet.

Diabetes type 1, the immune system of the body destroys its own cells that produces insulin, a hormone that needed the glucose (blood sugar) to enter the cells and feed them. On the other hand, diabetes type 2, is very opposite, the pancreas still produces the insulin but the cells are no longer reacting on it, which is known as insulin resistance.

Until today, diabetes don’t have significant treatment available, the diabetes type 1 patients still rely on insulin treatment for the rest but stem cell treatment looks to have promising result.

However, patients have diabetes type 2 can treat this disease by exercise, balance diet and medications but it may fall to insulin treatment.

Diabetes if not controlled or treated, have many complications such as blindness, kidney failure, feet ulcerations, amputations, neuropathy, etc.

Recently, a great news have emerge in the scientific areas. It is official now that diabetes have finally its vaccine now, which is promises to be a solution on diseases progression and it may reverse its effect.

This new vaccine can be used to treat both children and adults without any side effects, according to the researchers. They added that although immunizations are not cure, but a certain improvements had been notice on sample patients. Also they noticed, that each patients is unique and the disease progression depends on many factors. Patients who received this treatment have significant improvements.

Dr. Jorge Gonzalez Ramirez (creator of autohemotherapy), indicated that after 5 cubic of centimeters of blood is taken from patient, mix with 55ml of saline and cooled in five degrees Celsius.

When the blood is drawn out the body, the average temperature is 37 degrees and when cooled to a temperature of 5 degrees, a thermal shock occurs which corrects metabolic and genetic mistakes. This mixture then injected back to the patient. The vaccine last 60 days and the treatment last for a year.

Dr. Ramirez said, “This vaccine is much more than a drug; it is a medical practice. We see it as an alternative, a possible solution to stop chronic degenerative complications: stroke, hearing loss; amputation, kidney failure and blindness, among many others. “

To avoid complications, the patients should collaborate with the doctors because this a treatment not 100% cure. Together with this vaccines, patient should continue with regular exercise and diet, to achieve the maximum result in order to avoid any complications.

This new discovery might be the answer to many patients suffering diabetes. Hopefully, this treatment will able to cure the diabetes in the future.

Please share this to anyone and this might help to anyone with diabetes.

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Research say; If you want to be happy? Eat More Fruits and Vegetables

Recently, a research had been conducted in University of Warwick, telling that eating more fruit and vegetables have significantly increases people’s level of happiness. This research will be publish shortly to a prestigious American Journal of Health. This study is one of the major attempt to explore the psychological aspect beyond the finding that fruits and vegetables can reduce the risk of cancer and heart attacks.

 During the research, happiness had been detected for consuming fruits and vegetables for up to 8 portion per day.

Researcher concluded that people who consumed eight portion of fruits and vegetables from not consuming any of it, find themselves to be satisfied life which have equivalent to moving from unemployment to employment. Those people’s well-being occurred in 24 months.

This study have followed more than 12,000 randomly selected people. They will keep a food diaries and have their psychological well-being measured. The researcher found out that within 24 months, a large positive psychological benefits occurred on the subjects.

 "Eating fruit and vegetables apparently boosts our happiness far more quickly than it improves human health. People's motivation to eat healthy food is weakened by the fact that physical-health benefits, such as protecting against cancer, accrue decades later. However, well-being improvements from increased consumption of fruit and vegetables are closer to immediate," said by Professor Andrew Oswald of University of Warwick.

The researcher found out that happiness increases when an extra potion daily of fruits and vegetables up to eight portions being consume. This study is a collaboration between University of Warwick in England and University of Queensland in Australia.

Many professor thinks that it may possible to link this study to the current research into antioxidants that might have a connection between optimism and carotenoid in the blood. But, many others thinks a further research is needed on this area.

According to Dr. Redzo Mujcic, of University of Queensland “Perhaps our results will be more effective than traditional messages in convincing people to have a healthy diet. There is a psychological payoff now from fruit and vegetables—not just a lower health risk decades later."

Authors found out that alterations in fruits and vegetables intake predictive of later alterations in life satisfaction and happiness. Also, this alteration may be influence in changes, such income and life’s circumstances.

Note: It may be lengthen or shorten from the source.